CBD oil for depression
This article aims to be informative about the properties of CBD and its effect on the brain. As well as its use as a possible treatment for depression and anxiety, conditions that can arise in different age groups and for many various reasons.
History of Cannabis
Cannabis Sativa L is the scientific name for hemp. It is an annual dioecious herbaceous plant native to which grows in many regions, including tropical areas and temperate climates.
The ancient use of this substance has been linked to its analgesic properties. It has been used to increase the pleasure of food and music, and as support for religious meditation. Its first medical indications as an anaesthetic, hypnotic or analgesic date from a Chinese medicine book 4700 years ago.
Cannabis produces naturally high concentrations of chemicals known as cannabinoids. The two main cannabinoids are CBD (cannabidiol) and THC (tetrahydrocannabinol). THC is the cannabinoid responsible for the psychoactive effect that is the goal of most cannabis consumption.
The chemical composition of CBD
THC and CBD are the two most naturally abundant cannabinoids, THC represents about 12-25%, and CBD is 1-4% approximately. CBD has similarities with THC, only that CBD is not considered psychoactive in nature. Its chemical formula is C21H30O2, and its molecular weight (like THC) is 314.46 g/mol. CBD oil is available in capsules, aerosols, groceries and other products. CBD oil contains more CBD than THC (approx 5% CBD v usually less than 0.2% THC), and even though the total amount of CBD may seem small, it is sufficient to produce the desired effect.
CBD has the advantage of not being psychoactive, which means people are able to purchase it without needing a medical prescription from a qualified physician. They can also use CBD without the fear of being intoxicated or risking an overdose that could seriously affect their health. CBD is regarded as safe although it is not recommended to be used alongside existing medication unless a GP or medical specialist has first been consulted.
CBD is currently being researched to assess its analgesic, antidepressant, and anxiolytic (anti-anxiety) effects. It is also being analysed to determine if it possesses neuroprotective properties, which, if they exist, could help prevent degenerative diseases like Parkinson's. This area requires a lot of research, and with the passage of time, has taken a more vital role. In general, clinical evidence is crucial for the legal acceptance of CBD, primarily because in some countries, it is not yet well known or socially acceptable.
What is depression and how we can classify it?
Depression is defined by the World Health Organization as a very common mental disorder, which is characterised by the presence of sadness, loss of interest or pleasure, feelings of guilt or lack of self-esteem, sleep or appetite disorders, feeling fatigue and lack of concentration.
Depressed patients can be divided into three groups according to their symptoms:
The first group manifests depressive symptoms such as sadness, feelings of guilt or suicidal ideation. It tends to affect people with low self-esteem and can cause delusional thoughts, thoughts of death, or suicide ideation. The second group has symptoms that are not visible at first sight or are not associated directly with depression, like insomnia, anorexia, fatigue, headache, and dizziness.
Symptoms such as anxiety are predominant in the third group, which is also often misdiagnosed and mistreated. According to Watts, anxiety is the most common mask in depression, which can be accompanied by sweating of the hands, dryness of the mouth, oesophagal bolus, the sensation of emptiness in the stomach and tightness in the chest.
Secondary depression improves by eliminating an organic disease or by suspending the drug that causes it. -Cases with more severe symptoms should be referred to the psychiatrist. These are patients with a high risk of suicide or history of previous attempts, who suffer frequent and severe relapses. Also, those who do not respond to treatment or who have an organic disease that contraindicates the use of antidepressants. Some examples are myocardial infarction, glaucoma, and prostatism.
Cannabidiol is now the focus of many research studies which hope to determine if it could have a positive effect on people suffering from depression
Through various studies, it has been found that CBD is a 5-HT receptor agonist. This receptor is located in the central nervous system, which is responsible for regulating the expression of serotonin. This is an exciting discovery and could be one of the properties of CBD that may in the future enable it to be prescribed to alleviate anxiety and depression. 5-HT is responsible for controlling a series of biological and neurological processes, such as anxiety, appetite, sleep, the perception of pain, nausea, and vomiting. For anxiety, depression, spasms and pediatric convulsive disorders, many medical marijuana patients initially find that they do better with a moderate dose of a cannabis remedy dominant in CBD. This is a combination of CBD and THC, and will probably have a more significant therapeutic effect for a broader range of conditions than the CBD or THC alone.
CBD is a safe compound which may have a wide range of therapeutic applications, including the treatment of psychiatric disorders. Multiple research findings make this compound an attractive candidate for future clinical trials. There is hard animal research evidence that shows CBD can have a positive impact on depression. And animal studies have shown that the use of CBD can affect serotonin levels in the body and improve sleep patterns.
It is also common, that with depression appetite can decrease. This is something in which CBD can help significantly. People suffering from depression can experience insomnia, which can be improved with a moderate dose of CBD Oil.
At the same time, conditions like depression and appetite disorders lead in consequence to metabolic deregulation and coincide with a systemic proinflammatory state. Patients with increased appetite have higher resistance to insulin leptin, PCR, IL-1 and IL-6, and less ghrelin than subjects in other groups. The magnitude of their insulin resistance correlated positively with the response of insula (a small region of the cerebral cortex) to signs of food.
Changes in appetite and weight are frequent symptoms of depression, with nearly half of patients experiencing depression-related loss of appetite, and approximately a third experiencing depression-related increases in hunger. In an earlier study, researchers found that depressed adults with appetite change showed marked differences in brain activity to food cues.
So, research is now intensifying to discover if CBD oil could in the future be used to help those patients with loss of appetite, potentially improving their health and lifting depression at the same time. It's important to note that your primary physician or a medical professional should be consulted to ensure you do not have an inflammatory state in your body that could affect possible outcomes when consuming CBD oil.
According to some studies, the areas of the brain that play an important role in depression are the amygdala, thalamus, and hippocampus. People suffering from depression and anxiety have a smaller hippocampus, which directly affects memory and cognition. CBD induces neurogenesis (growth of brain cells/connections), which potentially means it may have the ability to help to regenerate neurons. This could possibly be a successful treatment for depression and anxiety.
A Study on a ten-year-old girl
The University of Colorado's School of Medicine conducted a study on a ten-year-old girl who was diagnosed with PTSD after an incident of sexual abuse. The patient received non-pharmacological treatment to treat anxiety and depression, i.e. only natural nutrition and CBD oil to control the symptoms, for 5 months.
It was observed; as a result, an improvement of the depression, improving sleep, and she was even able to sleep in her own room at the end of the treatment, showing normal behaviour. This research study concluded that CBD oil is sufficient to reduce anxiety, in this case, caused by post-traumatic stress. CBD oil needs more research and studies to assess whether it could be the natural way to cure depression, leaving people's health in optimal condition, without adverse effects while protecting their brain.
Not only is CBD being studied for its potential use for anxiety-related symptoms, but it is also a source of omega oils as well as EFA's and GLA's, and it brings a host of other dietary advantages along with it. CBD oil is rich in over 110 other cannabinoids, and with a healthy endocannabinoid system, you eat well, you sleep well, you have fantastic body-mind balance, and you kick stress and anxiety out. It’s a no-brainer, really.
A healthy endocannabinoid system can also decrease the likelihood of relapse in depression. Other protective factors against a decline into depression include having a balanced diet, exercise, avoid at all costs a sedentary lifestyle, learn how to handle stressful situations, having good family support and good value on the work you do. If you decide to try CBD oil and notice any unfavourable reaction to CBD consumption, you should go to your doctor and stop using it until the cause of the side effect has been identified.